Green Tea Extract Reduces Rat Lung Fibrotic

  • Desdiani
  • Iris Rengganis
  • Samsuridjal Djauzi
  • Agus Setiyono
  • Mohammad Sadikin
  • Sri Widia A. Jusman
  • Nurjati Chairani Siregar
  • Suradi
  • Putri C. Eyanoer
Keywords: green tea extract, lung fibrotic, Aschroft’s modified scale, fibropreventive, fibrolysis.

Abstract

Background
Pulmonary fibrosis is often found in infectious diseases and chemical exposure in the work environment. Antifibrotic effects can be
fibropreventive and fibrolysis. Bleomycin can cause inflammation and pulmonary fibrosis. Catechin is proven can repair liver
damages due to alcohol induction. The aim of this study is to examine the effect of antifibrotic green tea catechin on reducing the
area of rat lung fibrotic.
Methods
This research was carried out in vivo experimentally in the Laboratory Animal Management Unit at Faculty of Veterinary Medicine
IPB in 4 groups of rat experiments, consisting of 3 rats in the negative control group, 3 rats in the positive control group, 3 rats in the
group of rats given bleomycin on the 8th day and 28th
with green tea extract every day from day 0 to 49 days (fibropreventive), 3
groups of rats given bleomycin days 0 and 21 with green tea extract every day from day 15 to 49 (fibrolysis). Histopathological
examination was performe for all groups of rats.
Results
This study showed that administration of green tea extract in fibropreventive groups and fibrolysis groups could reduce the fibrosis
area in rat lungs based on Aschroft's modified scale.
Conclusion
Based on the results of this study it was found that the anti-fibrotic activity of green tea extract was proven to be able to suppress
the development of pulmonary fibrosis both by fibropreventive and fibrolysis

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Published
2020-01-20
Section
Articles