An Accuracy Comparison of SOX10 with DOG1 Immunohistochemistry in Diagnosing Acinic Cell Carcinoma of Salivary Gland in Paraffin Tissue Samples

Abstract

Background
Morphological diversity is a challenge in establishing diagnosis of malignant tumor originated from salivary gland, especially Acinic
cell carcinoma (ACC). Immunohistochemical (IHC) staining using DOG1 is often used to help diagnosis of ACC. Lately, IHC SOX10
has been reported to have almost the same accuracy to DOG1 staining. This evidence-based case report aims to determine the
accuracy of SOX10 to DOG1 immunohistocheinstry staining in establishing a diagnosis of ACC.
Methods
Literature searches were carried out on the Pubmed, Clinical key, Proquest, ScienceDirect, Scopus, SpringerLink and Wiley
databases. Two journals were relevant to the clinical scenario, then a critical review is carried out using the Diagnostic Study
Appraisal Worksheet from the Center for Evidence-based Medicine, University of Oxford, 2010.
Results
The accuracy of SOX10 in diagnosing ACC was slightly better than DOG1, with sensitivity reaching 100% and specificity reaching
87.76%. The sensitivity of SOX10 and DOG1 is the same, but SOX10 is more specific, and positive predictive value is also better
than DOG1.
Conclusion
The accuracy of SOX10 is better than DOG1 in diagnosing ACC of salivary gland. However, the intensity of SOX10 staining tends to
be rather low compared to DOG1. Therefore, further research is still needed to recommend SOX10 staining in daily practice.