The Relationship between Inflammatory Cell Infiltration Density and the Clinicopathology of Colorectal Carcinoma in Dr. Mohammad Hoesin General Hospital-Palembang

Abstract

Background
Colorectal carcinoma has become one of primary problem that caused mortality and morbidity around the world. This malignancy
has contributed almost more than 9% of all cancer incidence. Lymphocyte infiltration density (TILs) is one of prognostic factors to
evaluate colorectal cancer. Although some studies have found that there still have variations in sassociation lymphocyte density with
clinicopathology of colorectal carcinoma which related to patient prognosis. This study was aimed to identify and analyze the
association of lymphocyte density with clinicopathological colorectal carcinoma patients in Dr. Mohammad Hoesin General Hospital
Palembang.
Methods
A total of 41 HE stained slides which were diagnosed as colorectal carcinoma were observed under the light microscope.
Lymphocytes were counted in five different areas that showed the highest lymphocytes density. The mean values of the lymphocyte
were received from those five different areas. Determination of cutoff point was counted from the median of all mean value of the
lymphocytes and being classified to become two categories, high-density lymphocytes and low-density lymphocytes.
Results
Out of 41 subjects, most patients have tumor size more than/or equal to 5 cm (63.4%), the tumors are often found in the left-sided of
colon (39.0%), have moderate differentiated degree (65.9%), are included into T3 in tumor staging (48.8%), and no regional lymph
nodes metastasis (39.0%). The most histopathological classification is adenocarcinoma (41.5%). Bivariate analysis showed that
lymphocyte density has correlation with tumor differentiation degree (p=0.021) and histopathological classification (p=0.004).
Conclusion
Lymphocyte infiltration density has correlation with degree differentiation and histopathological classification of colorectal carcinoma
in Dr. Mohammad. Hoesin General Hospital-Palembang