Association Between Histopathological Grade of Sarcoma and Radiotherapeutical Response.

Abstract

Background
Sarcomas are rare, aggressive tumors originating from mesenchymal tissue. Radiotherapy is currently accepted as the
standard adjuvant to the treatment of high-grade sarcomas, whereas low-grade sarcomas are controversial, but the response of
radiotherapy to sarcomas is up to 50%. The aim of this study was to determine the association between the histopathological
grade of sarcoma and the radiotherapeutical response.
Methods
The research design was a cross-sectional study, with retrospective analysis. The sample consisted of 80 paraffin block tissues
from biopsy and surgery specimens of sarcoma from January 2013 to December 2019 at Hasan Sadikin Hospital in Bandung,
consisting of 45 radiosensitive samples and 35 radioresistant samples. All samples were assessed for histopathological grade
according to the FNCLCC. Statistical analysis used the Chi-Square test with a significant value of p <0.05. Data were processed
using SPSS version 24.0 for windows.
Results
In the radiosensitive group, 15 (33.3%) samples were low grade sarcomas and 30 (66.7%) samples were high grade sarcoma.
There was no statistically significant association between histopathological grade and radiotherapeutical response in sarcomas
p> 0.05 (p = 0.304).
Conclusion
In this study, the radiotherapeutical response was not associated to the histopathological grade of sarcoma. This is because of
the sensitivity of radiotherapy is influenced by other factors including molecular characteristics.