Histopathologic Factors Affecting Metastases to Lymph Nodes in Laryngeal Squamous Cell Carcinoma in the Department of Anatomical Pathology FKUI/RSCM 2015-2019

  • Ela Laelasari
  • Lisnawati
Keywords: laryngeal squamous cell carcinoma, lymph node metastases, histopathologic.

Abstract

Background
Laryngeal squamous cell carcinoma (LSCC) is the second most common epithelial carcinoma of the head and neck. This carcinoma
has a poor prognosis if there have been metastases in the neck lymph nodes and did not get proper therapheutical management.
The aims of the study is to determine the histopathologic characteristics of LSCC with partial or total laryngectomy and neck
dissection, as well as its relationship with the incidence of metastases to lymph nodes.
Methods
Analytical descriptive study with cross-sectional design of secondary data on LSCC cases obtained through total or partial
laryngectomy accompanied by neck dissection from the archives of the Department of Anatomic Pathology FKUI / RSCM from
January 2015 to December 2019. The histopathological data obtained were analyzed by comparative statistical test.
Results
KSSL was more frequently found in men as much as 155 cases (94.5%) with the most common age was over 60 years old. In this
study, LSCC with lymph nodes metastases was found in 65 cases, the most common was tumor size >4 cm in 40 cases (61.5%),
medium differentiated tumors in 47 cases (72.3%), pT3-pT4 in 57 cases. (87.7%). There was a significant association between
metastasis to cervical lymph nodes with tumor size, poorly differentiated tumors, lymphovascular invasion and pT3-pT4.
Conclusion
Histopathologic factors including tumor size, pT3-pT4, poor differentiation, lymphovascular invasion are factors that play a role in the
occurrence of metastases to cervical lymph nodes in LSCC

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Published
2022-05-01
Section
Articles