Clinicopathological Profile of Prostate Adenocarcinoma Cases at Cipto Mangunkusumo Hospital in 2010-2019 with Special Overview of Robotic Biopsy

  • Gusti Rizky Prasetya
  • Meilania Saraswati
  • Agus Rizal AH. Hamid
  • Sahat BRE. Matondang
Keywords: prostate adenocarcinoma, WHO/ISUP grade, biopsy, robotic technique, PIRADS


Prostate adenocarcinoma is second most common malignancy in men and fourth leading death cause from malignancy worldwide. Prostate
biopsy is the gold standard for diagnosing this disease. However, the difficulty of sampling is a weakness in this procedure. In Cipto
Mangunkusumo hospital, biopsy technology is now available with robotic techniques for biopsy sampling, which is expected to increase
prostate biopsy accuracy. This study was to determine prostate adenocarcinoma case profile in the Department of Pathology Anatomic Cipto
Mangunkusumo Hospital for 10 years and to examine differences in sampling of biopsy preparations with robotic and non-robotic techniques.
This study was an exploratory descriptive study with cross-sectional design to determine prostate adenocarcinoma case profile in the
Department of Anatomic Pathology FKUI-RSCM for 10 years. The data obtained between the Gleason score of prostate biopsy preparations
and surgery. Robotic prostate biopsy results were compared with prostate imaging reporting and data system (PIRADS) score.
The mean age of the patients was 67 years old and several patients were aged <50 years old. Many poor differentiation cases were found. It
appears that there is a relationship between WHO/ISUP degree and perineural invasion. In 14 patients who underwent histopathological
examination more than once, it was found that 9 patients had the same WHO/ISUP degree and 5 patients had a changed WHO/ISUP
degree. There are several discrepancies in PIRADS score and histopathological findings from 21 robotic preparations examined.
The mean age of patients fit to theory of generalized prostate adenocarcinoma. Many cases of poor differentiation were found, possibly
related to RSCM as a national referral center. The repeated sample examination results are similar to the results of other studies. Roboticmethod biopsy gives the sense of more comprehensive sampling in comparison to non-robotic method.


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