Clinicopathological Features of Neoadjuvant Chemotherapy Response to Triple Negative Breast Cancer in Dr. Hasan Sadikin General Hospital

  • Widya Savitri
  • Bethy Surjawathy Hernowo
  • Sri Suryanti
Keywords: triple negative breast cancer, TNBC, clinicopathology, response to neoadjuvant chemotherapy, FAC

Abstract

Background
Triple Negative Breast Cancer (TNBC) accounts for 9-17% of all breast cancer diagnoses. TNBC has a high proliferation index and a poor
prognosis with a higher response rate to neoadjuvant chemotherapy, but does not correlate with Overall Survival (OS) due to
chemoresistence in more than 50% of TNBC. Neoadjuvant chemotherapy with anthracycline (doxorubicin) based regimens in combination
with fluorouracil and cyclophosphamide (FAC) is still an option for TNBC. The aim of this study was to determine association between
clinicopathological profile and response to neoajuvan chemotherapy in TNBC at Dr. Hasan Sadikin Bandung which is a referral hospital in
West Java.
Methods
This study used an analytic observational method with a cross-sectional design. The research sample consisted of 40 TNBC cases from
January 2017 to December 2019 at Dr. Hasan Sadikin hospital. Data obtained from medical records and archives of the Anatomical
Pathology Laboratory consist of clinical response to neoadjuvant chemotherapy, age, tumor size, lymph node metastases and distant
metastases, clinical stage, type of histopathology and lymphovascular vessel invasion.
Results
In 40 cases of TNBC, 20 cases responded and 20 cases did not respond to neoadjuvant chemotherapy. In the non-response group, there
were 90% of cases with histopathologic type invasive carcinoma of no special type and 75% showed invasion of lymphovascular vessels.
There were no significant differences in age, tumor size, lymphovascular vessel invasion, stage, or histopathological type in the response
and non-response groups.
Conclusion
There is no correlation between clinicopathological features and neoadjuvant chemotherapy response in the case of Triple Negative Breast
Cancer (TNBC). This can be caused by other factors including high heterogeneous tumor microenvironment (TME).

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Published
2022-09-12
Section
Articles