Hubungan Ekspresi Imunohistokimia Cyclooxygenase-2 (COX-2) dengan Derajat Histopatologi Meningioma

Authors

  • Indri Mahrani
  • Delyuzar
  • Joko S. Lukito

Keywords:

cyclooxygenase-2, histophatologic grading, immunohistochemistry, meningioma

Abstract

Background
Meningioma is the most common intracranial primary neoplasm in adults, which arise from arachnoid cap
(meningothelial) cells. Histological appearance of a meningioma is an important predictor of tumor behavior.
Cyclooxygenase-2 (COX-2) enzyme is overexpressed in different types of tumors and is known to be
associated with malignant behavior of tumors. The aim of this study was to evaluate cyclooxygenase-2 (COX-2)
immunoreactivity in meningioma and to find association with histopathologic grading of meningioma.
Methods
This is an analytical descriptive study with cross sectional approach. The histopathologic grading of 22 samples
of meningioma were determined and stained with COX-2 immunohistochemistry. The color intensity: 1 (mild), 2
(moderate), 3 (strong). Percentage of positive cells: 0 (0%), 1 (<10%), 2 (10-50%), 3 (>50%). The evaluation
was the sum of color intensity and percentage of positive cells: positive (>4), negative (<4).
Results
Twnty two cases of meningioma: mean age=41 years, 90.9% females, meningothelial=22.7%, grade I=77.3%).
COX-2 expression: negative: 17 cases (77,3%) all was first degree of malignancy. COX-2 positive: 5 cases
(22,7%): 4 cases of second degree and 1 case of third degree of malignancy. The expression of COX-2 in
meningioma cells was associated with WHO histopathologic grading (p=0.001).
Conclusion
This study showed a relationship between COX-2 immunohistochemical expression and histopathologic grading
of meningioma, where COX-2 was more expressed in grades II and III.

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Published

2019-09-03

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