Detection of Micrometastasis in Bulky Lymph Nodes Cervical Carcinoma Stage IA-IIB Using Cytokeratin AE1/AE3

Authors

  • Reni Angeline
  • Hartono Tjahjadi
  • Puspita Eka Wuyung

DOI:

https://doi.org/10.55816/mpi.v29i3.441

Keywords:

bulky lymph nodes; cervical carcinoma stage IA-IIB; cytokeratin AE1/AE3; micrometastasis

Abstract

Background
Cervical uterine carcinoma is a primary malignant disease of the uterine cervix. The presence or absence of metastasis in lymph
nodes does not alter the stage but affects recurrence, survival, and therapy. Immunohistochemistry stains of the AE1/AE3
cytokeratin can assist in the diagnosis and determine the small focus of carcinoma metastasis. In this study, we analyzed
immunohistochemistry cytokeratin AE1/AE3 could determine micrometastasis in bulky lymph nodes negative.
Methods
This study used cross-sectional design. The sample consisted of 52 cases of stage IA-IIB cervical carcinoma performed by radical
hysterectomy and lymphadenectomy accompanied by negative bulky lymph nodes at the Department of Anatomical Pathology
Faculty of Medicine University of Indonesia/Cipto Mangunkusumo Hospital (FKUI/RSCM) from January 2011 to June 2017. All
cases stained by immunohistochemistry cytokeratin AE1/AE3.
Results
Bulky Lymph Nodes Cervical Carcinoma stage IA-IIB, histopathologic diagnose of non keratinized squamous cell carcinoma,
moderate differentiation degree, no lymphovascular invasion and deepest invasion >5.0 mm. Immunohistochemistry staining of
AE1/AE3 cytokeratin showed no micrometastasis in all cases.
Conclusion
The immunohistochemistry staining of AE1/AE3 cytokeratin used in Bulky Lymph Nodes Cervical Carcinoma stage IA-IIB could not
detected micrometastasis in all cases.

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Published

2020-09-07

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Articles