Clinicopathological Characteristics and the Relationship between Histological Grade with Luminal B Breast Cancer in RSUP Mohammad Hoesin within 2014-2016

Authors

  • Reihan Putri Awaliah
  • Citra Dewi
  • Riana Sari Puspita Rasyid

DOI:

https://doi.org/10.55816/mpi.v31i1.488

Keywords:

breast carcinoma, molecular subtype, luminal B, histopathological grade

Abstract

Background
Breast carcinoma is the second highest malignant disease that causes death in Indonesia with 58,256 new cases in 2018. Luminal
B has more aggressive clinical behavior and is considered as having unfavorable prognosis. This study aimed to determine the
clinicopathological characteristics and the relationship histological grade with breast carcinoma subtype molecular luminal B.
Methods
This is a descriptive analytic study with cross sectional design using secondary data of breast carcinoma patients registered at
RSUP Mohammad Hoesin Palembang during the period of January 1st, 2014 to December 31st, 2016.
Results
From 903 breast carcinoma patients in Mohammad Hoesin Hospital Palembang during 2014 to 2016, 43.63% had luminal B
molecular subtype. The highest incidence and prevalence washappened in year 2016, whichwere 4.7 and 4.4 per 10 breast
carcinoma patients, respectively. The majority of breast carcinoma of luminal B molecular subtype occurs in the group of patients
aged ≥40 years (81.7%), female (98.7%), Malay race (100%), marital status (98.8%), housewives (68.3%), histopathological
carcinoma of invasive non-specific type (75.9%), high grade/ grade III (63.7%), localized (60.6%), no metastases (60.0%), rightsided tumor laterality (50.8%) and with negative HER2 (65.2%). There was a significant relationship between the histopathological
grade and breast carcinoma luminal B molecular subtype (p=0.009).
Conclusion
The incident of breast carcinoma molecular subtype luminal B at Mohammad Hoesin Hospital Palembang has increased in the last
three years with the poor clinicopathological characteristics.

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Published

2022-01-04

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