Hubungan Ekspresi Reseptor Progesteron dan Ki-67 Labeling Index dengan Derajat Histopatologik Meningioma

Abstract

Background
Meningioma is tumor originating from meningothelial cells (arachnoid) attached to duramater. These is the
second most tumor in central nervous system. All degrees meningioma have risk for recurrence, unfortunately
the biologic behavior of meningioma can’t be seen from histopathology alone. Therefore, many studies have
shown progesterone receptor influence the degree of meningioma and Ki-67 LI also has important role in
determining risk of recurrence in the degree meningioma. Therefore, the examination of progesterone receptor
and Ki-67 LI in meningioma is required to see character of meningioma tumor cells and hence to determine
treatment and prognosis.
Methods
The study was a cross-sectional study, which conducted patients with diagnosis of meningioma from 5
Pathological Anatomy Laboratories in West Sumatra. Total of 64 cases meningioma were obtained during
January 2012 to December 2015 and 35 samples were taken and met the inclusion criteria.
Immunohistochemical examination was using specific antibodies to progesterone receptor and Ki-67. Data
collected were analyzed using the Kruskal-Wallis test and p value <0.05 was considered as statistically
significant.
Results
From 35 samples, 29 samples (82.9%) classified meningioma grade I, 4 samples (11.4%) meningioma grade II
and 2 samples (5.7%) meningioma grade III. Meningioma was most prevalent the age range 41-50 years,
female gender and histopathological grade I.
Conclusion
No differences expression progesterone receptor on the degree histopathological meningioma. No differences
expression Ki-67 LI on the degree histopathological meningioma. There is inverse relationship between
expression progesterone receptor and Ki-67 LI on the degree histopathological meningioma