Hubungan Ekspresi Matriks Metaloproteinase-9 dengan Jenis Histopatologi Karsinoma Serviks dan Invasi Limfovaskular

Abstract

Background
Matrix Metalloproteinase 9 (MMP-9) is a proteolytic enzyme assumed to have an important role in cervical
carcinogenesis. Limfovascular invasion (LVI) and higher expression of MMP-9 will make cervical tissue
degradation faster, invasion process and metastasist easier. Adenocarcinoma is suspected of having poor
prognostic than squamous cell carcinoma (SCC). The aim of this study was to examine the relationship
between expression of MMP-9 with histopathological cervical carcinoma and LVI.
Methods
A cross sectional analytic study was performed on 36 sample that divided into 18 KSS and 18 adenokarsinoma.
Samples were tooken from block paraffin from surgery or biopsy in Anatomic Pathology laboratories are located
in West Sumatra. Sample are reviewed and found the LVI. Immunohistochemical was staining with primary
antibody MMP-9 then its expression were assessed in stroma and cytoplasmic cell tumour.
Results
MMP-9 expression was found positive in 80.6% (41.1% for SCC and 58.6% for cervical adenocarcinoma. The
mean of expression of SCC was 17.4 and cervical adenocarsinoma was 19.56. Expression of MMP-9 was
positive in LVI sample.
Conclusion
There is not significant relationship between the expression of MMP-9 with type of histopatologic cervical
carcinoma (p=0.088) and LVI (p=0.566). Expression of MMP-9 in cervical adenocarcinoma was higher than
SCC, but it was not significant (p=0.563).