Analysis of Cyclin D1 and COX-2 Expressions in Various Histopathological Grading of Ovary Endometrioid Carcinoma

Abstract

Background
Ovarian endometrioid carcinoma accounts for 10-15% of ovarian carcinomas, representing the second most common form of
ovarian epithelial malignancy. Epithelial cell lines stably transfected to overexpress COX-2 exhibit a higher proliferation rate and an
inhibition of apoptosis by prolongation of the G1 phase of the cell cycle through effects on Cyclin D1. The aim of this study is to
analyzed the correlation and differences between Cyclin D1 and COX-2 expressions in various histopathology grading ovarian
endometrioid carcinoma.
Methods
An analitycal obsevational design with cross-sectional approach on sample from 23 paraffin blocks in Anatomical Pathology
Laboratory Dr. Soetomo General Hospital. Microscopic slide stained with Cyclin D1 and COX-2 antibody. The imunohistochemistry
expression are evaluated and analyzed using Kruskal Wallis and Spearman test.
Results
There were no differences Cyclin D1 expression in each grade, there were no differences COX-2 expression in each grade, there
was no correlation between Cyclin D1 and COX-2 expression all histopathologic grading, but have correlation expression in grade 3
ovarian endometrioid carcinoma.
Conclusion
This study showed that Cyclin D1 and COX-2 expression have no significant differences in various histopathological grading ovarian
endometrioid carcinoma, and no correlation between Cyclin D1 and COX-2 expression all grade ovarian endometrioid carcinoma