Correlation between AgNOR Expression and Ki-67 Expression with Prostate Adenocarcinoma Grading

Abstract

Background
Prostate cancer is the second most common cancer and fifth most common cancer cause of death in males. Tissue biopsy is a gold
standard examination to diagnose prostate cancer. One of the hallmarks of cancer is increased activity of cell proliferation. This
activity can be detected with Ki-67 and AgNOR (Argyrophilic nucleolar organizing region). The aim of this study is to analyzed
correlation between AgNOR and Ki-67 expression in grading of prostated adenocarcinoma.
Methods
This analytic cross-sectional study was held in Laboratory of Anatomical Pathology of Medical Faculty of USU/ RSUP H. Adam
Malik Medan. Thirty paraffin blocks diagnosed with prostate adenocarcinoma were stained with H&E and p63 immunohistochemistry
then evaluated based on Gleason’s histopathological grading and stained with Agnor and Ki 67.
Results
AgNOR expression yang diperoleh pada grading adenokarsinoma prostat group 1, 2, 3, 4, dan 5 berturut-turut adalah 43; 32,40
(±14,54); 64,29 (±28,2); 59,5 (±28,32); 69,22 (±29,26). Ekspresi Ki-67 pada setiap grading adenokarsinoma prostat group 1, 2, 3, 4,
dan 5 secara berurutan adalah 43; 32,4 (±14,53); 64,29 (±28,2), 59,5 (±28,31); 69,22 (±29,26). Statistical analyses showed that
there was no significantly correlation between grading of prostate adenocarcinoma and AgNOR expression (p=0.065), and Ki-67
expression (p=0.18). Nevertheless, a significantly correlation between KI-67 expression and grading of prostate adenocarcinoma
was found (p=0.34).
Conclusion
Ki-67 could be used as prognostic indicator for prostate adenocarcinoma.