Association Between Clinicopathologic Characteristics and WHO Prognostic Group in Gastrointestinal Stromal Tumor Patients at RSUP Dr. Mohammad Hoesin, Palembang

Abstract

Background
Gastrointestinal stromal tumors are the most common mesenchymal tumors in the gastrointestinal tract. Based on tumor size and
mitotic index, WHO classified GIST into three prognostic groups which were benign, uncertain malignant potential, and malignant.
Some studies revealed that there was variation in association between age, gender, tumor location, histopathologic type and prognosis
of GIST patients. This study aimed to identify and analyze the association between clinicopathologic characteristics and WHO
prognostic group in GIST patients at RSUP Dr. Mohammad Hoesin Palembang.
Methods
This study used 30 medical records of GIST patients during 01 January 2014 to 27 December 2018 in the Department of Anatomic
Pathology RSUP Dr. Mohammad Hoesin. Clinicopathologic characteristics and WHO prognostic group data were collected. The
association between clinicopathologic characteristics (age, gender, tumor location, histopathologic type) and WHO prognostic group
were analyzed by chi-square test.
Results
From 30 subjects, 40% of the patients aged 52-58 years.There was no gender predilection. A total of 33.3% of the GISTs were located
in the small intestine. Majority of histopathologic type was spindle cell type (93.3%). Bivariate analysis showed there were no significant
association between clinicopathologic characteristics: age (p=0.811), gender (p=0.682), tumor location (p=1.000), histopathologic type
(p=0.469) and WHO prognostic group.
Conclusion
There was no significant association between clinicopathologic characteristics and WHO prognostic group in GIST patients at RSUP
Dr. Mohammad Hoesin Palembang. We suggest doing a cohort study about association between clinicopathologic characteristics and
survival rate in GIST patients.