Analyses of Fibroblast Activation Protein (FAP) Expression Rate to Clincopathology Factors and Chemotherapy Response in Ovarian Epithelial Malignant Tumors

Abstract

Background
Epithelial ovarian carcinoma is the most common cause of death among gynecological malignancies in the women. The interaction
among cancer cells and tumor microenvironment plays roles in cancer proliferation and invasiveness. One of important component of
tumor microenvironment that could stimulate tumor proliferation and invasiveness, is fibroblast. Activated fibroblasts also known as
carcinoma associated fibroblasts (CAFs). The purpose of research is to analyzed FAP expressions to clinicopathologic characteristic
(histopathology subtype and clinical stadium of FIGO) and chemotherapeutic responses.
Methods
This study is a retrospective observational analytic study with cross-sectional designs was undertaken during January 1, 2016 to June
30, 2018. The sample was 55 paraffin block sample epithelial ovarian carcinomas consists of 11 samples for each histopathology
subtype collected used purposive sampling technique. All samples were immunostained with FAP antibody. FAP expressions was
evaluated based on Min Shi et al studies. It analyzed stained area/ proportion (P) and intensity (I). Statistical analysis using chi-square
was performed using SPSS version 17.
Results
Patients of 40-49 years old (24; 43.6%), clinical stadium is III (30; 54.5%), Complete response (CR) of chemotherapeutic response
(38; 69.1%). The statistic analyses between histopathology subtypes (p=0.038), clinical stadium of FIGO (p=0.000) and chemotherapy
response (p=0.000) showed significant differences.
Conclusion
FAP expressions could showed correlation between clinicopathologic characteristic (histopathology subtype and clinical stadium of
FIGO) and chemotherapeutic response.