Analysis of Clinicopathological Characteristics in Luminal A like subtype Breast Carcinoma

Abstract

Background
Molecular subtypes of breast carcinoma, luminal A like has the best prognosis, but in the previous studies there were cases that
showed poor clinical outcomes. This study attempted to investigate the clinicopathological characteristics in luminal A like subtype
breast carcinoma.
Methods
This study is a cross sectional study. The samples used were 67 medical records of patients with luminal A like subtype breast
carcinoma in January 2014 to June 2019 period from Hasan Sadikin Hospital, Bandung. According to estrogen receptor (ER) and
progesteron receptor (PR) expression status by adding both intensity and distribution scores, the data were divided into two
subgroups: low histoscore (<7) and high histoscore (≥7). Clinicopathological characteristics (age, TNM stage, treatment, location,
histologic type, grading and metastasis) were evaluated for each subgroup.
Results
From 67 luminal A like subtype breast carcinoma patients, 73.13% were in the high histoscore subgroup, with higher percentage of
low grade histopathologic features (63.27%). There were no significant differences in age and TNM staging between the two
subgroups. Among 67 breast carcinoma patients, 43 were diagnosed in advanced stages. There were significant differences in
lymph nodes metastasis between the two subgroups (p-value 0.013), however, there were no significant difference in metastasis to
other organs.
Conclusion
This study shows that 73.13% of patients with luminal A like subtype breast carcinoma have a high histoscore of hormone receptor.
Low histoscore subgroups luminal A like subtype breast carcinoma will metastasize to lymph nodes.