Clinicopathological Profile of Invasive Breast Cancer with Distant Metastases in Anatomical Pathology Department FKUI/RSCM 2019

Abstract

Background
Invasive breast carcinoma (IBC) is the highest incidence and is the leading cause of malignancy-related death in women in the
world. Bones are the most common sites of IBC metastases. This study aims to provide clinical and histological characteristic data
in cases of distant metastastic IBC in the Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto
Mangunkusumo General Hospital (PA-FKUI/RSCM).
Methods
This is descriptive research with cross-sectional design, using secondary data from the archives of PA-FKUI/RSCM, starting from
January 1, 2019 to December 31, 2019.
Results
Distant metastases of IBC was found 65.2% as bone metastases, 46.1% as pulmonary metastases, 26.1% as liver metastases, and
8.7% as brain metastases. The largest age group was 40-59 years, median age was 49 years with range 27-78 years. The most
common of the classification of primary tumor size was 54.8% T4, and 87% unilateral cases. Most histologic subtypes were 90.4%
cases no special type, then lobular and mucinous subtypes. Lymphovascular invasion was 24.3% cases. The most common
molecular subtype was luminal B Luminal and mostly as bone metastases and triple negative breast cancer (TNBC) in lung
metastases. The greatest histological grade was grade 2.
Conclusion
Bone was the most common IBC metastatic. The most common of the classification of primary tumor size was T4 and histologic
subtype was no special. Luminal B was the most common molecular subtypes and the highest was bone metastases.