Diagnosis Accuracy of Fine Needles Aspiration Assessment in Bone Tumors in the Department of Anatomical Pathology FKUI/RSCM 2015-2019

Abstract

Background
Fine needle aspiration biopsy (FNAB) is a safe and rapid technique and has an important role in making the preoperative diagnosis
of bone tumors because it can help clinicians determine treatment for patients. This retrospective study aims to assess the accuracy
of the FNAB cytological examination compared with the histopathological examination in preoperative diagnosis of bone tumors.
Methods
The data comes from the archives of the Department of Anatomic Pathology, FKUI/RSCM 2015-2019 in the form of a cytological
examination of FNAB lesions on bone. Then the histopathological examination data were searched for each cytology preparation.
There were 133 pairs of cytology, and histopathology preparations. The preparations were reviewed by the investigator and
supervisor, assessed for the suitability of the cytologic diagnosis, and compared with the histopathological diagnosis.
Results
There were 84 (63.2%) cases of malignant tumors, 44 (33.1%) cases of benign tumors, and 5 (3.7%) cases of non-tumors. The
diagnostic test results showed an accuracy rate of 86.5% with a sensitivity of 85.9%, a specificity of 100%, a positive predictive
value (PPV) of 100%, and a negative predictive value (NPV) of 21.7%.
Conclusion
FNAB cytology examination of bone tumors that have adequate sample quality, supported by complete clinical information and
informative radiological images can produce an accurate preoperative diagnosis