Hubungan Tumor Infiltrating Lymphocytes Volume(TILV) dengan Grading Histopatologi pada Invasive Breast Carcinoma Of No Special Type

Abstract

ABSTRACT

Background

Invasive breast carcinoma of no special type (IBC-NST ) is a heterogeneous group of IBC-NST and cannot be classified morphologically as one of the histological images of a special type. The incidence of breast cancer in Indonesia in 2020 ranked first for the number of new cases in women. The new study says the assessment of Tumor-Infiltrating Lymphocytes (TILs) still does not reflect the full immune response because it is not aimed at the overall tumor stroma percentage. From previous studies Tumor-Infiltrating Lymphocyte Volume (TILV) is said to be better compared to TILs because it is not only to take into account TILs but also Tumor-Stroma Ratio (TSR) in assessing the immune capacity of tumors and as a prognostic predictor to estimate overall survival in patients with breast cancer.

Method

This study used a type of analytical descriptive research, using 36 slides of IBC-NST cases from RSUP H.Adam Malik Medan and the Department of Anatomic Pathology, Faculty of Medicine, North Sumatra.

Results

The most IBC-NST grading is grade 3, the most IBC-NST TILs stromal value is poor TILs, the TSR value of IBC-NST is stroma poor (TSR high), the most Tumor-Infiltrating Lymphocyte Volume (TILV) value is TILV Low, Tumor Infiltrating Lymphocyte Volume (TILV) has a strong correlation with IBC-NST histopathological grading.

Conclusion

Assessment of Tumor-Infiltrating Lymphocyte Volume associated with grading can be used as an indication of prognosis in patients with invasive breast carcinoma of no special type.