Histopathological Profile Of Extranodal Lymphoma: A Retrospective Study For 5 Years In Tertiary Care Hospital

Abstract

Introduction

Extranodal lymphomas account for 30% of all lymphomas. The diverse location and various clinical manifestation of extranodal lymphoma lead to difficulty in diagnosis. The different types of extranodal lymphoma behave and respond differently to therapy. The information regarding the incidence of extranodal lymphoma is still limited, hence further study is needed.

Methods

Descriptive observational research design with a retrospective approach. This study used data from anatomical pathology examinations at the Dr. Soetomo General Academic Hospital, Surabaya, over a 5-year period, with the diagnosis of lymphoma originating from organs other than lymph nodes and no prior history of lymphoma in the lymph node.

Result

As many as 379 cases were diagnosed as lymphoma originating from extranodal. The highest age group was 51-60 years old (27.70%), male patient is slightly higher (55.91%) and the highest location is in the head and neck region (48.11%). On anatomical pathology examination, the most common diagnosis were high grade B cell NHL (48.11%).

Conclusion

This study showed the incidence of extranodal lymphoma, with the majority of cases occurring in the fifth decade of life, with M:F ratio is 1.33:1 and the most common location was in the head and neck area. The most common histological diagnosis was high grade B cell NHL, with DLBCL being the most common subtype. This study provided initial information on the epidemiology of extranodal lymphoma at Dr. Soetomo General Academic Hospital in Surabaya. Further research is needed to determine the relationship between variables and patient survival.