The Differences of Histomorphologic Profiles of Liver Tissue of Resipient and Donor Postpaediatric Liver Transplantation between Rejection and Non Rejection Patients in Anatomical Pathology Department of FKUI/RSCM 2010-2019

Abstract

Background
Liver rejection is an immune system response of recipient in which attacking the antigen originating from a donor that can cause
damage to the transplanted organ. Although the prevalence of liver rejection has decreased due to the use of immunosuppressive
drugs, it is estimated that 20-40% of recipients still experience rejection and are at risk of re-transplantation and even death. This
study aims to investigating histomorphological characteristics that can play a role as risk factors for rejection by assessing the
differences in histomorphological characteristics before transplantation between recipient groups with rejection and non-rejection in
pediatric liver transplant recipients in the Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Dr.
Cipto Mangunkusumo (PA-FKUI/RSCM)
Methods
This study was an analytical study with a cross sectional design, using secondary data from the archives of the Department of
Anatomical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo 2010-2019. The clinical and
histopathologic data obtained were analyzed using comparative statistical tests.
Results
Rejection were found in 25% of recipients. Rejection were more common in the group of recipients aged >1 (75%), male (58%),
cirrhosis 4C (92%) and mild portal inflammation (56%). Rejection were more common in the group of donor with male (66%) and
steatosis ≤10% (92%). There were no significant differences in the histomorphological profiles of recipients and donors with or
without rejection.
Conclusion
The histomorphologic profiles of both recipients and donors were known to be descriptively associated with complications of posttransplant liver rejection. However, in terms of analysis, there was not any significant differences