Relationship of Stromal Tumor Infiltrating Lymphocytes (STILs) with Grading Histopathology in Penis Squamous Cell Carcinoma

Abstract

ABSTRACT

Background:Penile squamous cell carcinoma is the  most common penile malignance found in the world. Assessment of  stromal tumor infiltrating lymphocytes (STILs) associated with grading against  penile squamous cell carcinoma can provide  a potential prognostic picture  and help determine the action.

Method:Cross-sectional  analytical study  with 32 samples of histopathological preparations diagnosed as  penile squamous cell carcinoma  at H. Adam Malik Hospital Medan. The assessment of stromal TILs was carried out by assessing the number of lymphocyte inflammatory cells in  the peritumoral stroma and then determined the assessment score, zero score no lymphocytes (minimum), score one found 0-10% lymphocytes (moderately), score two found 20-40% lymphocytes  (massive) , score three found 50-90% lymphocytes. Grading assessments are categorized into  grade  I (well differentiated), grade  II (moderately differentiated), and  grade III  (poorly  differentiated).  

Result:The most grading found was grade II (43.8%) and the most STILs found were score three (50.0%). There is a significant relationship between grading and  STILs in  penile squamous cell carcinoma  (p value=0.0001) i.e. the higher  the STILs score  , the lower  the tumor grade.

Conclusion:There is a relationship between STILs and  histopathological grading in Penile Squamous Cell Carcinoma  so that it can be used as an indikasi prognosis in patients with  penile squamous cell carcinoma.