Relationship of CD117 Expression and Epidermal Growth Factor Receptor (EGFR) to Histopathological Grading of Adenoid Cystic Carcinoma in Salivary Glands

Abstract

Background
Tend to have adenoid cystic carcinoma (AdCC) is one of malignant epithelial tumor of the salivary gland poor prognosis, local
recurrence and metastases. Histopathological grading system according Weert, et al. observed from presence or absence solid
component of AdCC. CD117 is a transmembrane tyrosine kinase receptor usually strong expression in AdCC. EGFR belongs to the
ErbB family of receptor tyrosine kinases associated with cell proliferation, angiogenesis and metastases. Patients with advanced
disease may benefit from targeted therapy besides conventional management. Expression of CD117 and EGFR may give proposal
therapy through difference histology pattern of AdCC based on histopathological grading.
Methods
This is an analytical descriptive study with cross sectional approach. Formalin-fixed paraffin-embedded sections from 35 adenoid
cystic carcinomas were obtained for histopathological grading and for immunostained of CD117 and EGFR using monoclonal
antibodies. The staining intensity and percentage of cells with membranous and cytoplasmic of CD117 and EGFR expression were
scored and then grouped according to the parameters of the Allred scoring system.
Results
Chi-square test between CD117, EGFR expression and histopathological grading of AdCC showed no sigficant differences.
Besides, McNemar test between CD117 and EGFR expression and histopathological grading AdCC showed significant differences,
p-value=0.03 (p<0.05).
Conclusions
CD117 and EGFR could be used to detected salivary gland AdCC